Carboxylic acids and derivatives
Medchemexpress LLC Lei 101 hydrochloride | 2250025-91-1 | 508.99 g/mol | 50mg
LEI-101 is a potent selective and orally bioavailable cannabinoid CB2 receptor agonist with a pEC50 of 8 for hCB2 and a pKi of less than 4 for hERG LEI-101 is 100-fold more potent in binding to CB2 receptors than to CB1 receptors[1][2]
Medchemexpress LLC 1,2-Dilauroyl-sn-glycerol | 60562-15-4 | 98.0% | 50 MG
1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol that may be involved in second messenger signal transduction. It appears as a white to off-white solid with a molecular formula of C27H52O5 and a molecular weight of 456.70. This product is intended for research use only.
- Purity of 98.0%
- CAS number: 60562-15-4
- Soluble in DMSO (100 mg/mL), requiring ultrasonic for dissolution
- Ships at room temperature within the continental US
- Recommended storage for powder: -20°C for 3 years
- Recommended storage for in-solvent solutions: -80°C for 6 months, or -20°C for 1 month (aliquot and store to prevent inactivation from repeated freeze-thaw cycles)
- Related to metabolic enzymes/proteases and endogenous metabolites
- Acts as an inhibitor
Medchemexpress LLC AVN-101 hydrochlorid 10mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 10 MG
AVN-101 hydrochloride is the hydrochloride salt of AVN-101, a brain-penetrant, orally active antagonist of serotonin 5-HT7 receptors used in preclinical CNS research. It is supplied as a high-purity solid for in vitro and in vivo studies.
- Potent 5-HT7 receptor antagonist with additional activity at 5-HT6, 5-HT2A, 5-HT2C, H1, and α2 adrenergic receptors.
- Brain-penetrant and orally active, suitable for CNS pharmacology studies.
- High purity solid (LCMS purity 99.59%) for reliable experimental results.
- Chemical identity: 1H-pyrido[4,3-b]indole hydrochloride; formula C21H25ClN2; Mw 340.89.
- Recommended storage: sealed at -20°C; solvent storage guidance available from supplier.
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-10mM/1mL
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Apexbio Technology LLC CUDC-101 1012054-59-9 50mg
CUDC-101 (CAS 1012054-59-9) is a multitargeted small molecule inhibitor that concurrently targets epidermal growth factor receptor (EGFR) HER2 and class I and II histone deacetylases (HDACs) By inhibiting EGFR and HER2 kinases directly and simultaneously blocking HDAC activity CUDC-101 downregulates multiple oncogenic signaling pathways including those mediated by Akt HER3 and MET Preclinical assessments demonstrate that CUDC-101 inhibits growth of diverse tumor cell lines and xenograft models notably including those resistant to EGFR-targeted agents such as lapatinib and erlotinib These characteristics render CUDC-101 valuable for oncology research and drug resistance studies
Medchemexpress LLC Ji-101 | 900573-88-8 | MFCD26142530 | 99.8% | 466.33 | C22H20BrN5O2 | 10 MG
JI-101 is an orally available multi-kinase inhibitor that targets VEGFR2, PDGFRβ, and EphB4 and has demonstrated potent anti-cancer activity. It is provided as a white to off-white solid powder for research use and is commonly supplied in a 10 mg pack.
- Orally available multi-kinase inhibitor active against VEGFR2, PDGFRβ, and EphB4.
- High purity (99.78%).
- Molecular formula C22H20BrN5O2; molecular weight 466.33 g/mol.
- White to off-white solid, soluble in DMSO at ≥ 100 mg/mL.
- Intended for research use only; not for human administration.
Medchemexpress LLC Vnt-101 | 2894060-67-2 | 456.41 | C21H23F3N2O6 | 10 MG
VNT-101 is a small-molecule, orally active inhibitor of influenza A virus nucleoprotein (NP) oligomerization. It disrupts NP-NP protein-protein interactions to destabilize the viral ribonucleoprotein complex and has been used in vitro and in vivo to study antiviral activity across multiple influenza A subtypes.
- Disrupts nucleoprotein oligomerization to inhibit viral replication.
- Orally bioavailable small molecule suitable for in vivo studies.
- Demonstrated activity against multiple influenza A subtypes.
- Molecular weight 456.41 and molecular formula C21H23F3N2O6.
- CAS number 2894060-67-2 for substance identification.
- Supplied as a solid for research use with supporting characterization data.
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | 574.66 | C28H35FN4O6S | 10 MG
VH 101, acid is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand developed for PROTAC research and conjugation chemistry. The molecule includes an E3 ligase recognition motif and an alkyl linker terminating in a primary amine, facilitating attachment to target protein ligands.
- Designed for use as a VHL E3 ligase ligand in PROTAC development.
- Alkyl linker with terminal amine enables straightforward conjugation chemistry.
- High reported purity suitable for research applications.
- Supplied in small research-scale quantities for synthetic work and assay testing.
Medchemexpress LLC 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine | 59752-57-7 | MFCD00042828 | 98.0% | 579.75 g·mol⁻1 | C29H58NO8P | 50 MG
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine lipid with lauric (12:0) acyl chains. It is commonly used as a lipid component for preparing liposomes and for studies of membrane composition in biochemical and biophysical research.
- High purity suitable for research applications.
- Useful for liposome synthesis and membrane composition studies.
- Available in multiple small pack sizes for laboratory use.
- Contains lauric (12:0) acyl chains for defined lipid composition.
- Molecular weight 579.75 g·mol⁻1 and formula C29H58NO8P for accurate formulation.
TARGETMOL CHEMICALS INC PKUMDL-LC-101-D04 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4) a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 uM in a cell-free assay and at a concentration of 61 uM in wild-type but not Gpx4-/- mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 uM) reduced cholesterol peroxide-induced MEF death. purity: 98%
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 10 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It functions as an allosteric modulator, inducing sustained inhibition of EAAT1 through an intramonomeric site within the trimerization domain. In vitro studies show that UCPH-101 inhibits EAAT1 anion currents in a concentration-dependent manner, with a KD value of 0.34±0.03 μM. This compound is intended for research use only.
- Inhibits excitatory amino acid transporter subtype 1 (EAAT1)
- Functions as an allosteric modulator
- Demonstrates sustained inhibition of EAAT1 anion currents
- IC50 of 0.66 μM
- KD value of 0.34±0.03 μM for EAAT1 anion currents
Medchemexpress LLC PKUMDL-LC-101-D04 100mg | 2143896-83-5 | 378.9 | C14H22N4O2S2 · HCl | 100 MG
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research to modulate ferroptosis and lipid-peroxide-mediated cell death. It increases GPX4 enzymatic activity in biochemical assays and has demonstrated activity in cell extracts and cellular protection assays.
- Allosteric activator of glutathione peroxidase 4.
- Increases GPX4 activity to about 150% in a cell-free assay at 20 μM.
- Restores GPX4 activity in cell extracts at 61 μM.
- Reduces cholesterol hydroperoxide-induced cell death in mouse embryonic fibroblasts.
- High purity research-grade material suitable for biochemical and cellular assays.
- Molecular weight 378.9 and formula C14H22N4O2S2 · HCl.
Apexbio Technology LLC LOXO-101 1223405-08-0 25mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-1g
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2